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Triclabendazole
Predict NMR spectrum
RN: 
68786-66-3
MF: 
C14H9Cl3N2OS
MW: 
359.65726
InChI:  1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
InChIKey:  NQPDXQQQCQDHHW-UHFFFAOYSA-N
H donor:  1
H acceptor:  3
Rotatable bond:  3
Stereocenter:  0
cLogP:  5.704
cLogS:  -6.949
Polar surface:  63.21
NEW: 3D model: 
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  Supplier     Description     Reference  
bocsci Triclabendazole, >98%
on request
amadischem Triclabendazole, 98%
Bulk, semi-bulk
advtechind triclabendazole, crm standard
on request
100 MG
leapchem triclabendazole, 98%
on request
leapchem triclabendazole
on request
leapchem triclabendazole
on request
alfa-chemistry Triclabendazole
alfa-chemistry Triclabendazole
1g
5g
10g
25g
100g
250g
alfa-chemistry Triclabendazole(CGA89317) is a benzimidazole, it binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.Target: Microtubule/TubulinTriclabendazole treatment produces percentage decreases of the fluke egg output by 15.3%, 4.3% and 36.6%, respectively, in sheep, dairy cows and heifers, these results indicate the presence of TCBZ-resistant Fasciola hepatica in sheep and cattle on this farm . Triclabendazole sulphoxide (50 mg/mL) results in extensive damage to the tegument of triclabendazole-susceptible F. hepatica, whereas triclabendazole-resistant flukes shows only localized and relatively minor disruption of the tegument covering the spines .Triclabendazole is metabolized into a number of compounds, depending on the route of administration, plasma levels peak at 18-24 hours (Triclabendazole sulphoxide) and 36-48 hours (Triclabendazole sulphone), neither Triclabendazole nor any toher metabolites can be detected in plasma. Triclabendazole sulphoxide blocks the transport of secretory bodies from the cell body to the tegumental surface, the block occurs at the site of their formation by the Golgi complex in the cell body, in their movement through the cytoplasmic connections to the syncytium, and in their movement from the base to the apex of the syncytium. Triclabendazole binds to the colchicine binding site on the β-tubulin molecule and this has been used at the basis for evaluating the relative acitvity of Triclabendazole ., 98.72%
1g
5g
10g
25g
100g
250g
chemieliva 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzo[d]imidazole, 98%
5G
10G
20G
50G
100G
50KG
chemieliva Triclabendazole, 98%
5G
10G
20G
50G
100G
50KG
carbonesci Triclabendazole, 98%
on request
qcsrm Triclabendazole
rosewachem Triclabendazole
on request
001chemical 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzo[d]imidazole, NLT 98%
on request
lingruichem Triclabendazole
on request
chempur 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzo[d]imidazole/ 95%
100 g
and other units
chempur Triclabendazole/ >97%
100 mg
and other units
synblock Triclabendazole, NLT 98%
on request
chempur Triclabendazole
1 g
and other units

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