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Rhein

Predict NMR spectrum
RN: 
478-43-3
MF: 
C15H8O6
MW: 
284.22492
mp (°C): 
321  - 322
InChI:  1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
InChIKey:  FCDLCPWAQCPTKC-UHFFFAOYSA-N
H donor:  3
H acceptor:  6
Rotatable bond:  1
Stereocenter:  0
cLogP:  2.438
cLogS:  -4.151
Polar surface:  111.9
NEW: 3D model: 
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  Supplier     Description     Reference  
amadischem Rhein, 98%
Bulk, semi-bulk
advtechind rheum palmatum root plant extract emodin,rhein
on request
INQUIRY
advtechind rhein, certified reference material
on request
20MG
advtechind rhein tech 90%
on request
250MG
on request
50MG
alfa-chemistry Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.IC50 value:Target:In vitro: Rhein (0.1 and 1 mg/mL) evidently suppressed cell proliferation and mitogen-activated protein (MAP) kinase activation in human colon adenocarcinoma cells (Caco-2) but significantly lessened H2O2-induced DNA damage and the elevated MDA and ROS levels induced by H2O2/Fe2+ at the concentrations of 0.1-10 mg/mL .In vivo: Oral administration of rhein (150 mg/kg/d) evidently ameliorated renal interstitial fibrotic lesions and attenuated the expression of α-SMA and deposition of fibronectin (FN) in mice with renal interstitial fibrosis induced by unilateral ureteral obstruction. Rhein also suppressed TGF-β1 and its type I receptor expression in obstructed kidneys . The biochemical parameters results of IgAN model rats showed that rhein-prevented and rhein-treated both improved the biochemical parameters and relieved renal pathological injury. The expressions of renal tissue TLR4, TGF-β1, but not TLR9 were significantly elevated in IgAN model rats (P < 0.05). Rhein-prevented and rhein-treated both inhibited TLR4 and TGF-β1 expressions ., 95%+
1g
5g
10g
25g
100g
250g
leapchem rhein
on request
leapchem rhein
on request
alfa-chemistry Rhein, 95%+
1g
5g
10g
25g
100g
250g
cm-finechemicals Rhein
Research
Pilot
bocsci Rhein, > 98 %
chemieliva 4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid, 98%
10G
20G
50G
100G
50KG
5G
chemieliva Rhein, 98%
10G
20G
50G
100G
50KG
5G
rosewachem 4,5-Dihydroxyanthraquinone-2-carboxylic Acid
on request
manchesterorganics 1,8-Dihydroxyanthraquinone-3-carboxylic acid
5 g
10 g
qcsrm Diacerein EP Impurity C
biosynth
Rhein
on request
bocsci Rhein, > 98 %
advtechind rhein 95+%hplc
10MG
activate-scientific 4,5-Dihydroxyanthraquinone-2-carboxylic acid, 98%
1.0g
5.0g
25.0g
chempur 1,8-Dihydroxy-3-carboxyanthraquinone/ 95%
100 g
and other units

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